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BIOINORGANIC CHEMISTRY AND METALS IN MEDICINE

Module code: CH407C
Credits: 5
Semester: 2
Department: CHEMISTRY
International:

	Overview
	Bio-Inorganic Chemistry. Entatic state and HSAB theory. Common ligand types found in biological systems. Structure of the 20 aminoacids. Potassium ion channels, sodium/potassium pump. Selective transport and storage of iron. Oxygen transport and storage. Molecular orbital theory of O2 molecules, ground state and excited state of O2. Oxygen and reactive oxygen species (ROS). Mechanism of action of Superoxodismutase, Catalase, Peroxidases and Cytocrome C oxidase enzymes. Electron transfer (cytochromes, iron-sulphur clusters, copper enzymes). Acid-base catalysis (zinc enzymes). Zinc fingers proteins. Reactions of cobalt-containing enzymes. Metal-Based Drugs: Historic perspective of the uses of metal ions in medicine. Details of selected metallo-therapeutics such as gold, platinum and ruthenium. Metal-based radiopharmaceuticals. Magnetic resonance imaging agents.

Overview

Bio-Inorganic Chemistry. Entatic state and HSAB theory. Common ligand types found in biological systems. Structure of the 20 aminoacids. Potassium ion channels, sodium/potassium pump. Selective transport and storage of iron. Oxygen transport and storage. Molecular orbital theory of O2 molecules, ground state and excited state of O2. Oxygen and reactive oxygen species (ROS). Mechanism of action of Superoxodismutase, Catalase, Peroxidases and Cytocrome C oxidase enzymes. Electron transfer (cytochromes, iron-sulphur clusters, copper enzymes). Acid-base catalysis (zinc enzymes). Zinc fingers proteins. Reactions of cobalt-containing enzymes. Metal-Based Drugs: Historic perspective of the uses of metal ions in medicine. Details of selected metallo-therapeutics such as gold, platinum and ruthenium. Metal-based radiopharmaceuticals. Magnetic resonance imaging agents.

	Learning Outcomes
	On successful completion of the module, students should be able to: Describe the structures and functions of selected non-transition metal ions in the body. Describe catalytic cycles for enzymes containing transition metal ions. Describe the synthesis, structures and reactions of metal-based drugs. Understand the importance and the function of metal-based radiopharmaceuticals and MRI image enhancement agents.

Learning Outcomes

Teaching & Learning methods

Assessment

	Autumn Supplementals/Resits
	Are supplemental/resit registrations permitted? Yes University scheduled written examination (Autumn): 120 minutes Is Supplemental Continuous Assessment registration permitted? No Is Supplemental Continuous Assessment capped? No

	Pre-Requisites
	CH301C, CH302C, CH303C, CH311

	Timetable
	This timetable is not currently available, please contact the Chemistry Department.

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Courses / Module

BIOINORGANIC CHEMISTRY AND METALS IN MEDICINE