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BIOINORGANIC AND �F� BLOCK CHEMISTRY

Module code: CH427
Credits: 5
Semester: 2
Department: CHEMISTRY
International:

	Overview
	Bio-Inorganic Chemistry. Entatic state and HSAB theory. Common ligand types found in biological systems. Structure of the 20 aminoacids. Potassium ion channels, sodium/potassium pump. Oxygen transport and storage. Molecular orbital of O2 molecules, ground state and excited state of O2. Oxygen and reactive oxygen species (ROS). Mechanism of action of Superoxodismutase, Catalase, Peroxidases and Cytocrome C oxidase enzymes. Electron transfer (cytochromes, iron-sulphur clusters, copper enzymes). Acid-base catalysis (zinc enzymes). Zinc fingers proteins. Metal-Based Drugs: Historic perspective of the uses of metal ions in medicine. Details of selected metallo-therapeutics such as gold, platinum and ruthenium. Metal-based therapeutic radiopharmaceuticals and medical imaging agents. Magnetic resonance imaging - theory and f block contrast agents.

Overview

Bio-Inorganic Chemistry. Entatic state and HSAB theory. Common ligand types found in biological systems. Structure of the 20 aminoacids. Potassium ion channels, sodium/potassium pump. Oxygen transport and storage. Molecular orbital of O2 molecules, ground state and excited state of O2. Oxygen and reactive oxygen species (ROS). Mechanism of action of Superoxodismutase, Catalase, Peroxidases and Cytocrome C oxidase enzymes. Electron transfer (cytochromes, iron-sulphur clusters, copper enzymes). Acid-base catalysis (zinc enzymes). Zinc fingers proteins. Metal-Based Drugs: Historic perspective of the uses of metal ions in medicine. Details of selected metallo-therapeutics such as gold, platinum and ruthenium. Metal-based therapeutic radiopharmaceuticals and medical imaging agents. Magnetic resonance imaging - theory and f block contrast agents.

	Learning Outcomes
	On successful completion of the module, students should be able to: Describe the functions of selected non-transition metal ions in the body. Describe catalytic cycles for enzymes containing transition metal ions. Describe the role of metals in the mechanism of processing oxygen. Describe the synthesis, structures and mechanism of action of selected metal-based drugs. Discuss the chemistry of the f block elements and their spectroscopic and magnetic properties. Describe the uses of f block elements in the medical imaging.

Learning Outcomes

Teaching & Learning methods

Assessment

	Autumn Supplementals/Resits
	Are supplemental/resit registrations permitted? Yes University scheduled written examination (Autumn): 120 minutes Is Supplemental Continuous Assessment registration permitted? No Is Supplemental Continuous Assessment capped? No

	Pre-Requisites
	CH204/CH224; CH301C; CH302C/CH322; CH303C/CH323; CH311/CH331

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BIOINORGANIC AND �F� BLOCK CHEMISTRY

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