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The course will examine all aspects of vaccine design and delivery. Special attention will be paid to adjuvants and excipients building on concepts delivered in modules covering innate immunology. The bulk of the course will survey the rational design of vaccines and correlates of immunity . This will begin with the history of polio vaccines comparing the Salk v Sabin vaccines, the lesser known failed vaccines of the 1930s and the Cutter incident. The course will then survey all vaccines in common use and examine the particular challenges of protecting the neonate in the developing world. Finally the course will examine the prospect for novel vaccines against the three major poverty related infectious diseases (TB, HIV, malaria). Students will be expected to perform considerable reading of current literature in vaccinology and participate in a small group project.
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