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Chemical/enzymatic catalysis and the stereoselective formation of organic compounds.
This module overviews chemical and enzymatic catalysis with a focus on catalytic methodology, general and specific acid-base catalysis; mechanisms of enzymic catalysis - specific enzymes will be discussed; and organocatalysis.
Strategies to obtain organic molecules with control of stereochemistry is also covered and includes:
(i) stereochemical nomenclature;
(ii) resolution by formation of diastereomers through ionic and covalent bond formation, to include in situ racemisation, by the method of entrainment and by preparative chromatography on an optically active support;
(iii) diastereoselective synthesis including ring constrained substrates and chiral starting materials;
(iv) enantioselective synthesis by application of the chiral auxiliary, chiral reagent or chiral catalyst approach;
(v) methods to determine the d.e. or e.e. of a reaction, (vi) controlling the geometry of alkenes, and kinetic vs. thermodynamic control in alkene synthesis.
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CATALYTIC AND STEREOSELECTIVE ORGANIC CHEMISTRY
Semester 1
